Early environmental effects on epigenetic regulation in humans
نویسندگان
چکیده
منابع مشابه
Epigenetic gene regulation: early environmental exposures.
Environmental epigenetics Traditional research on the combined effects of genetics and the environment investigates how individuals differ in susceptibility to disease and how susceptibility changes over time. The majority of these gene–environment interaction studies focus on genetic sequence variants, including single nucleotide polymorphisms (SNPs), which influence toxicant uptake, metabolis...
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Major efforts have been directed towards the identification of genetic mutations, their use as biomarkers, and the understanding of their consequences on human health and well-being. There is an emerging interest, however, in the possibility that environmentally-induced changes at levels other than the genetic information could have long-lasting consequences as well. This review summarises our ...
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Influence of environmental exposure on human epigenetic regulation.
Environmental toxicants can alter epigenetic regulatory features such as DNA methylation and microRNA expression. As the sensitivity of epigenomic regulatory features may be greatest during the in utero period, when critical windows are narrow, and when epigenomic profiles are being set, this review will highlight research focused on that period. I will focus on work in human populations, where...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2009
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.4.8.10155